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sparsentan will reduce the level or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lessens efficacy relevant to these substrates.itraconazole will boost the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 m